課程資訊
課程名稱
分解性生醫材料
Degradable Biomaterials 
開課學期
107-2 
授課對象
學程  幹細胞與再生醫學學程  
授課教師
黃義侑 
課號
DBME7015 
課程識別碼
528 M0310 
班次
 
學分
3.0 
全/半年
半年 
必/選修
選修 
上課時間
星期四2,3,4(9:10~12:10) 
上課地點
 
備註
本課程中文授課,使用英文教科書。教室:基醫507室。
總人數上限:25人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1072DBME7015_ 
課程簡介影片
 
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課程概述

一、課程簡介: 學分數:3 學分
Biodegradable (and/or bioabsorbable) biomaterials are widely used in sutures, bone plates, guiding of growth of tissues, drug delivery systems and other types of prostheses. In drug delivery systems, such polymers offer the great advantage of enabling site-specific or systemic administration of pharmaceutical agents without the need for subsequent retrieval of the delivery system. This course will provide a board spectrum of biodegradable polymers, ranging from synthesis, characterization, manufacturing… to medical applications. It will be useful to students who are new to the field and would like to understand more about the various properties and medical applications of biodegradable polymers.

課程內容:包括
 1. Introduction: Classification and mechanisms of biodegradation.
 2. Biodegradable polyesters: Lactide/glycolide polymers
 3. Biodegradable polyesters and tissue engineering
 4. Polyanhydrides
 5. Poly--Caprolactone and its copolymers
 6. Poly(ortho esters)
 7. Polyphosphazenes as new biomedical and bioactive materials
 8. Pseudopoly(amino acids)
 9. Natural biodegradable polymers: Albumin, collagen, and chitin/chitosan
10. Collagen and artificial skin
11. Liposome: Preparation and characterization
 12. Medical applications of liposomes: Drug delivery and gene therapy

二、先修課程:無

三、參考書目:
1. Chasin M and Langer R: Biodegradable Polymers as Drug Delivery Systems. Marcel Dekker, 1990, New York.
2. Hollinger JO: Biomedical Applications of Synthetic Biodegradable Polymers. CRC Press, 1995, Boca Raton
3. Lanza RP, Langer R and Vacanti J: Principles of Tissue Engineering. Academic Press, 2000, San Diego. 

課程目標
This course will emphasize on the green plastcs, biodegradable macromolecules and polymers. That will be useful to students who are new to the field and would like to understand more about the various properties and medical applications of biodegradable polymers. 
課程要求
無 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
無 
參考書目
1. Chasin M and Langer R: Biodegradable Polymers as Drug Delivery Systems.
Marcel Dekker, 1990, New York.
2. Hollinger JO: Biomedical Applications of Synthetic Biodegradable Polymers.
CRC Press, 1995, Boca Raton.
3. Lanza RP, Langer R and Vacanti J: Principles of Tissue Engineering.
Academic Press, 2000, San Diego. 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2/21  BioDegradable Biomaterials- Introduction
(核心能力:2,3,4,7) 
第2週
2/28  二二八紀念日 放假 
第3週
3/07  Biodegradable Polymers for the Environment
(核心能力:2,4,6) 
第4週
3/14  Biodegradable Polymers for Medical Applications
(核心能力:2,4,7) 
第5週
3/21  Biodegradable Materials for Drug Delivery systems and Collagen
(核心能力:2,3,4,6) 
第6週
3/28  Biopolymers-Collagen and Gelatin
(核心能力:4,6,7) 
第7週
4/04  Spring Break 
第8週
4/11  Biopolymers-Chitosan
(核心能力:2,4,6) 
第9週
4/18  Mid-Term Quiz 
第10週
4/25  Hyaluronic Acid and its Derivatives
(核心能力:2,4,6,7) 
第11週
5/02  Polyhydroxyalkanoates
(核心能力:2,4,7) 
第12週
5/09  Synthetic polyester-PLA, PGA
(核心能力:2,3,4,7) 
第13週
5/16  Polyanhydride
(核心能力:2,4,6) 
第14週
5/23  Liposomes
(核心能力:2,4,7) 
第15週
5/30  PEGylation
(核心能力:2,4,7) 
第16週
6/06  Oral presentation
(核心能力:2,3,4,6) 
第17週
6/13  1.Oral presentation
2.Scaffold Fabrication
(核心能力:2,3,4,6) 
第18週
6/20  final test